Glacios

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Powerful Microscopes Resolve High Resolution Structures

With 4 Glacios microscopes, NIS has expertise in sample prep, vitrification, microscopy, data processing & workflows for projects of all stages & complexity.

We have multiple Glacios cryo-TEM instruments at both our East and West Coast facilities. This 200kV microscope is ideal for rapid grid screening to evaluate vitrification, as well as for characterizing nanoparticle therapeutics and vaccines.

Specifications

  • Source: High-brightness field emission gun (FEG)
  • Accelerating voltage: up to 200 kV
  • Cryo-Autoloader: Automated loading of cassettes, containing up to 12 Autogrids

Software

  • Temperature management software – Including liquid nitrogen autofill and cool down scheduling
  • Low-dose software suite minimizes electron dose during cryo-TEM operation(used for Sample Assessment, Optimization, and Automated Data Acquisition)

Lenses

  • Automatic condenser, objective and SA apertures
  • Symmetric constant power objective lens (minimize image aberrations and lens hysteresis during mode switching)

Stages

  • CompuStage with Single-Axis Holder

Cameras

  • Falcon 4 Direct Electron Detector OR Falcon 3EC Direct Electron Detector

Capabilities

  • Data collection > 400 images/hour
  • Drift rate: <1 nm / min