High-Resolution Protein Structures Through Macromolecular X-Ray Diffraction
X-ray crystallography provides near-atomic resolution 3D structures for targets where crystallization is achievable, complementing our cryo-EM capabilities to cover a broader range of structural biology targets.
With X-ray crystallography, our structural biologists can resolve near-atomic detail of protein-ligand interactions, supporting structure-based drug design and fragment-based screening programs.
The Workflow
Sample to Structure in 2 to 4 Weeks
Tailored X-ray Crystallography Solutions
Structure-Based Drug Design
Co-crystal structures of protein-ligand complexes that reveal binding modes and inform medicinal chemistry.
Fragment-Based Screening
Screening of small fragment libraries against protein crystal structures to identify novel hit-to-lead entry points.
Antibody & Biologics Characterization
Epitope mapping and biosimilar comparability studies at atomic resolution.
Enzyme Mechanism & Engineering
Capture of catalytic intermediates and high-resolution active-site structures to inform rational mutagenesis.
