One Study, Multiple Answers
Cryo-TEM imaging is a vital technique for nanoparticle characterization, providing detailed quantitative and qualitative information of your formulation with just one study.
Cryo-TEM and TEM imaging reveal Critical Quality Attributes (CQAs) and structural detailsthat other methods miss, using only a small amount of sample (~50μl). From development through manufacturing, we provide fast, flexible, and cost-effective access to the answers cryo-TEM and negative stain TEM can reveal.
Service Areas
Particle Morphology & Integrity
Cryo-TEM can unveil many aspects of a sample in just one study, including particle size distribution, shape,lamellarity, impurities, and integrity.
Payload Encapsulation & Distribution
Gain crucial answers, such as size and payload distribution, with our proprietary in-house-developed machine learning algorithms.
Stability
We use cryo-TEM to track particle size, morphology, and distribution over time and under different storage conditions so you can confirm your formulation maintains integrity and efficacy throughout its shelf life.
Comparability
From development through to GMP method validation and regulatory filings, negative stain TEM and cryo-TEM per-particle imaging complements your nanoparticle characterization toolkit in any stage of the pipeline.
Critical Quality Attribute (CQA) Analysis
Cryo-TEM is a powerful orthogonal technique to complement your nanoparticle characterization toolkit. Evaluate multiple quality attributes with one study.
What We Provide
- Unparalleled Partnership: High-quality cryo-TEM and TEM images and a seamless workflow, across the pipeline from R&D through method validation
- Unrivaled Insights: Crucial answers with proprietary in-house developed machine learning algorithms
- Unmatched Expertise: 240+ cumulative years of cryo-EM experience, the most experienced nanoparticle characterization CRO
Our Nanoparticle Experience
AAV samples imaged; 3D structure of AAV solved to 1.8 Å
Liposomal samples imaged, including LNP, EV, and OMV projects
Virus and VLP samples imaged
Samples We Image
- Adeno-Associated Virus (AAV)
- Adenovirus
- Bacteriophage
- Extracellular Vesicles & Exosomes
- Gold Nanoparticles
- Human Papillomavirus (HPV)
- Iron Nanoparticles
- Lentivirus
- Lipid Nanoparticles (LNPs), with mRNA, RNA, DNA payloads
- Liposomes
- Micelles
- Polymeric Nanoparticles
- Protein Based Nanoparticles
- Two Component Systems (such as adjuvanted formulations)
- Vesicular Stomatitis Virus (VSV)
