Cryo-EM Services

Streamline projects with optimized cryo-EM workflows

Cryogenic Electron Microscopy (cryo-EM) uses sophisticated Transmission Electron Microscopes (TEM) to directly visualize biological samples. It is particularly advantageous when studying challenging biological systems, such as macromolecular complexes in different functional states. Cryo-EM can overcome the challenges of traditional methods, providing structural information for samples in near-native states.

With cryo-EM, our structural biologists can answer questions regarding the interactions of small molecules with the chosen target and suggest ways to help design and optimize drug candidates, supporting a structure-based drug design approach.

We have six microscopes across our San Diego and Boston sites, including two Titan Krios and four Glacios instruments. This provides the most comprehensive industrial access in North America. We deploy negative stain and cryogenic techniques along with proprietary vitrification workflows to maximize the chance of success for your structural study.

We support both on-site and co-localized high speed computing resources consisting of more than 500 processing cores, 50 GPUs, and six petabytes of storage space, all located within secure facilities behind multiple high availability firewalls and following NIST security guidelines.