Streamlined Epitope Mapping
Gain near-atomic resolution results detailing epitope/paratope interactions of antibody-antigen complexes in two weeks
We visualize full antibody-antigen complexes and Fab fragments to define the precise structural basis of antibody-antigen interactions, using cryo-EM or X-ray crystallography depending on sample properties. Our team has a proven track record of handling the most challenging, non-crystallizable proteins, delivering high-resolution three-dimensional maps and structural data that are crucial for accelerating drug discovery.
Our Approach
Cryo-EM Epitope Mapping
High-resolution 3D structures of Fab-antigen or full antibody-antigen complexes to pinpoint specific amino acid interactions at the binding interface. With personalized cryo-EM workflows, sample to structure in as little as two weeks.
X-ray Crystallography Epitope Mapping
High-resolution 3D structures of Fab-antigen or full antibody-antigen complexes for samples amenable to crystallization, pinpointing specific amino acid interactions at the protein-protein interface.
Negative Stain TEM Screening
High-contrast screening to confirm complex formation and determine binding topology in days rather than weeks.
Target Classes
Our unparalleled structure determination experience includes:
- Antibody-Antigen Complexes
- Multi-protein Complexes
- Membrane Proteins
- Receptors
Integrated Workflow
Through our gene-to-structure workflow, we can express and purify recombinant IgG or Fab fragments, formulate the target antigen, assemble the complex, and deliver a high-resolution 3D structure via cryo-EM or X-ray crystallography. Recombinant antibody production is completed in 8-12 weeks using our fully licensed HEK and CHO cell lines.
