High-Resolution Structure Determination

Resolving near-atomic detail of ligand binding sites and interactions to accelerate drug design and development, we enable you to obtain functional insights into your macromolecules and biologics by visualizing your target's structural components and binding sites.

Using cryo-EM and X-ray crystallography, our structural biologists can answer questions regarding the interactions of small molecules with the chosen target and suggest ways to help design and optimize drug candidates, supporting a structure-based drug design approach.

Our advanced cryo-EM workflows deliver 3D protein structures in as little as two weeks, with personalized workflows that make projects simple and streamlined. Cryo-EM excels for non-crystallizable targets, membrane proteins, and large macromolecular complexes.

X-ray crystallography provides near-atomic resolution 3D structures for targets where crystallization is achievable, complementing our cryo-EM capabilities to cover a broader range of structural biology targets.

Our X-ray crystallography services support structure-based drug design and fragment-based screening programs.

• Antibody-Antigen Complexes
• GPCRs
• Ion Channels
• Multi-protein Complexes
• Membrane Proteins
• Soluble Proteins
• Protein Degraders & Ternary Complexes (PROTAC® Degraders, Molecular Glues)
• Protein-Nucleic Acid Complexes
• Receptors
• RNA
• Solute Carrier Transporters (SLCs)