Integrated Gene-to-Structure Workflow
An integrated workflow from construct design through expression, purification, and imaging, all overseen by a dedicated team
With decades of experience, our highly skilled scientists develop a customized, detailed workflow to ensure that you know each step of the project before work is initiated. Dedicated project managers monitor the process and communicate results in real time.
The Workflow
Gene to protein in 8-12 weeks. Our advanced cryo-EM workflows deliver 3D protein structures in as little as two weeks after sample receipt.
- 01
Construct Design & Expression
Customizable expression services in mammalian (HEK, CHO), insect (Sf9, Tni), and bacterial (E. coli) systems. Scalable transient production in shake flask culture up to 60 L.
- 02
Protein Purification
Customizable expression services in mammalian (HEK, CHO), insect (Sf9, Tni), and bacterial (E. coli) systems. Scalable transient production in shake flask culture up to 60 L.
- 03
Protein Analytics
Comprehensive protein analytics to characterize, quantify, and evaluate protein samples across multiple dimensions. Analytics packages are fully customizable to best suit your applications.
- 04
Structure Determination
Depending on sample type, structure determination proceeds via cryo-EM or X-ray crystallography, each with a personalized, streamlined workflow.
- Cryo-EM: Sample to structure in under four weeks — Feasibility Assessment, High Resolution Data Collection, 2D Class Averaging, 3D Structure Reconstruction.
- X-ray crystallography: Crystallization Screening, Crystal Optimization, X-ray Diffraction Data Collection, Structure Solution & Refinement.
