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Absolute configuration determination of pharmaceutical crystalline powders by MicroED via chiral salt formation

Bo Wang, Jessica F. Bruhn, Asmerom Weldeab, Timothy S. Wilson, Philip T. McGilvray, Michael Mashore, Qiong Song, Giovanna Scapin and Yiqing Lina

March 8, 2022

Unfortunately, kinematical refinement of MicroED data lacks the differentiation power to assign the absolute structure solely based on the measured intensities. Here we report a method for absolute configuration determination via MicroED by employing salt formation with chiral counterions.

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Citations & References

Wang B, Bruhn JF, et al. Absolute configuration determination of pharmaceutical crystalline powders by MicroED via chiral salt formation. Chem Commun (Camb). 2022 Apr 12;58(30):4711-4714. doi: 10.1039/d2cc00221c

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Authors

Bo Wang, Jessica F. Bruhn, Asmerom Weldeab, Timothy S. Wilson, Philip T. McGilvray, Michael Mashore, Qiong Song, Giovanna Scapin and Yiqing Lina

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