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Bleb formation induced by acidic mixing buffers improves liquid stability of mRNA-LNPs

Bleb formation induced by acidic mixing buffers improves liquid stability of mRNA-LNPs

March 16, 2026
Biophysical trade-offs in antibody evolution are resolved by conformation-mediated epistasis

Biophysical trade-offs in antibody evolution are resolved by conformation-mediated epistasis

March 12, 2026
Structural basis for DCAF2 as a novel E3 ligase for PROTAC-mediated targeted protein degradation

Structural basis for DCAF2 as a novel E3 ligase for PROTAC-mediated targeted protein degradation

October 2, 2025
The Discovery of RP-2119: A Potent, Selective, and Orally Bioavailable Polθ ATPase Inhibitor

The Discovery of RP-2119: A Potent, Selective, and Orally Bioavailable Polθ ATPase Inhibitor

September 7, 2025
Preclinical characterization of novel multi-client inhibitors of Sec61 with broad antitumor activity

Preclinical characterization of novel multi-client inhibitors of Sec61 with broad antitumor activity

July 31, 2025
A novel interleukin-10 antibody graft to treat inflammatory bowel disease

A novel interleukin-10 antibody graft to treat inflammatory bowel disease

March 5, 2025
The Cryo-EM structure of human serum albumin in complex with ligands

The Cryo-EM structure of human serum albumin in complex with ligands

August 31, 2024
Mechanistic insights into a heterobifunctional degrader-induced PTPN2/N1 complex

Mechanistic insights into a heterobifunctional degrader-induced PTPN2/N1 complex

August 15, 2024
Discovery of a Peptoid-Based Nanoparticle Platform for Therapeutic mRNA Delivery via Diverse Library Clustering and Structural Parametrization

Discovery of a Peptoid-Based Nanoparticle Platform for Therapeutic mRNA Delivery via Diverse Library Clustering and Structural Parametrization

August 5, 2024
High-Resolution Cryo-Electron Microscopy Structure Determination of Haemophilus influenzae Tellurite-Resistance Protein A via 200 kV Transmission Electron Microscopy

High-Resolution Cryo-Electron Microscopy Structure Determination of Haemophilus influenzae Tellurite-Resistance Protein A via 200 kV Transmission Electron Microscopy

April 19, 2024
Structural basis for the oligomerization-facilitated NLRP3 activation

Structural basis for the oligomerization-facilitated NLRP3 activation

February 6, 2024
Morphological Characterization of Self-Amplifying mRNA Lipid Nanoparticles

Morphological Characterization of Self-Amplifying mRNA Lipid Nanoparticles

January 3, 2024
Structural and mechanistic insights into the inhibition of respiratory syncytial virus polymerase by a non-nucleoside inhibitor

Structural and mechanistic insights into the inhibition of respiratory syncytial virus polymerase by a non-nucleoside inhibitor

October 20, 2023
Purification of a recombinant oncolytic virus from clarified cell culture media by anion exchange monolith chromatography

Purification of a recombinant oncolytic virus from clarified cell culture media by anion exchange monolith chromatography

July 2, 2023
Stressed stability and protective efficacy of lead lyophilized formulations of ID93+GLA-SE tuberculosis vaccine

Stressed stability and protective efficacy of lead lyophilized formulations of ID93+GLA-SE tuberculosis vaccine

June 18, 2023
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